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Case Reports
. 2013 Jan;8(1):42-7.
doi: 10.4103/1793-5482.110279.

Intracranial metastasis from primary spinal primitive neuroectodermal tumor

Rajesh Kumar Ghanta  1 , Kalyan Koti, Venkata Sateesh K Ghanta, Ramesh Teegala
Affiliations
Case Reports

Intracranial metastasis from primary spinal primitive neuroectodermal tumor

Rajesh Kumar Ghanta et al. Asian J Neurosurg. 2013 Jan.

Abstract

Primary spinal primitive neuroectodermal tumors (PNET) are rare tumors, with only 94 cases reported till date. Metastasis to brain from a spinal PNET is even rarer. In the present report, we evaluate the pathology and treatment of solitary intracranial metastasis from spinal PNET in a 22-year-old female who presented with headache and left hemiparesis and was diagnosed to have right parietal parasagittal tumor. She has been previously diagnosed to have cervicothoracic primary spinal PNET, and was treated by surgery, radiotherapy, and chemotherapy seven years back. The intracranial tumor has been removed and pathological examination confirmed as PNET. She received radiotherapy and chemotherapy with ifosfamide and etoposide, following surgery for the right parietal PNET. At 20 months follow-up, patient is stable and has no recurrence of the disease. Critical review of reported cases of primary spinal PNET metastsising to brain was done.

Keywords: CD 99; metastasis; primitive neuroectodermal tumor; spinal tumor.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
CECT of brain showing right parietal parasagittal metastatic tumor
Figure 2
Figure 2
(a) MRI of cervico-dorsal spine demonstrating C6-D2 spinal tumor with dumbbell like extension into upper thorax; (b) MRI axial images demonstrating spinal tumor at D-1 extending outside
Figure 3
Figure 3
PET scan five years after surgery for spinal PNET showing no evidence of recurrence/metastasis
Figure 4
Figure 4
(a) Histopathology showing densely cellular tumor arranged in sheets and lobules with minimal intervening stroma; (b) Immunohistochemistry showing membranous positivity for CD99
Figure 5
Figure 5
Post-operative CECT brain at nine months after surgery showing no evidence of tumor
See this image and copyright information in PMC

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