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. 2012 Jun 6;2(3):259-77.
doi: 10.1098/rsfs.2012.0012. Epub 2012 Mar 22.

A review of protein adsorption on bioceramics

Kefeng Wang  1 , Changchun Zhou, Youliang Hong, Xingdong Zhang
Affiliations

A review of protein adsorption on bioceramics

Kefeng Wang et al. Interface Focus. .

Abstract

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic-protein interactions.

Keywords: bioceramics; interface; protein adsorption.

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Figures

Figure 1.
Figure 1.
A schematic of the evolution of bioceramics.
Figure 2.
Figure 2.
Schematic of the inverse correlation existing between SSA, protein adsorption capacity of HA powder and protein adsorption and cell attachment and growth on sintered HA ceramics [88].
Figure 3.
Figure 3.
The top view of charged ions or groups distribution on (a) HA (001) and (b) OCP (100) planes. Ca, green; P, violet; O, red.
Figure 4.
Figure 4.
Diagram illustrating the importance of chemical and hydrophobic properties in protein adsorption [80].
Figure 5.
Figure 5.
The influencing factors of the protein adsorptions.
See this image and copyright information in PMC

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References

    1. Dorozhkin S. V. 2010. Bioceramics of calcium orthophosphates. Biomaterials 31, 1465–148510.1016/j.biomaterials.2009.11.0 (doi:10.1016/j.biomaterials.2009.11.0) - DOI - DOI - PubMed
    1. Best S. M., Porter A. E., Thian E. S., Huang J. 2008. Bioceramics: past, present and for the future. J. Eur. Ceram. Soc. 28, 1319–132710.1016/j.jeurceramsoc.2007.12.001 (doi:10.1016/j.jeurceramsoc.2007.12.001) - DOI - DOI
    1. Williams D. F. 2009. On the nature of biomaterials. Biomaterials 30, 5897–590910.1016/j.biomaterials.2009.07.027 (doi:10.1016/j.biomaterials.2009.07.027) - DOI - DOI - PubMed
    1. Allan B. 1999. Closer to nature: new biomaterials and tissue engineering in ophthalmology. Br. J. Ophthalmol. 83, 1235–124010.1136/bjo.83.11.1235 (doi:10.1136/bjo.83.11.1235) - DOI - DOI - PMC - PubMed
    1. Doremus R. H. 1992. Bioceramics. J. Mater. Sci. 27, 285–29710.1007/BF00543915 (doi:10.1007/BF00543915) - DOI - DOI