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. 1977 Nov 21;38(4):287-94.
doi: 10.1007/BF00352033.

[Investigations of carbromal metabolism (author's transl)]

[Article in German]
W Zimmermann, W Braun

[Investigations of carbromal metabolism (author's transl)]

[Article in German]
W Zimmermann et al. Arch Toxicol. .

Abstract

Erythro-2-Brom-2-ethyl-3-hydroxybutyramide has been isolated from the urines of patients with Carbromal intoxications as well as from the urine of rat, mouse and dog treated with either Carbromal or with 2-Brom-2-ethyl-acetamide. The identification of the excreted and synthetized metabolite was carried out by means of IR, Mass and NMR spectroscopy. Along with the erythro-2-Brom-2-ethyl-3-hydroxybutyramide one other bromine containing compound was isolated after Carbromal application only, its mass spectrum and rel. RF values having the same characteristics as the synthetized erythro-2-Brom-2-ethyl-3-hydroxybutyrylcarbamide. However, the purification of this metabolite so far has not been successful.

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