Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2013 Jun 6:12:188.
doi: 10.1186/1475-2875-12-188.

Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings

Daniel Eibach  1 , Boubacar Traore, Mourad Bouchrik, Boubacar Coulibaly, Nianégué Coulibaly, Fanta Siby, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot
Affiliations
Comparative Study

Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings

Daniel Eibach et al. Malar J. .

Abstract

Background: Malaria rapid diagnostic tests (RDTs) are a useful tool in endemic malaria countries, where light microscopy is not feasible. In non-endemic countries they can be used as complementary tests to provide timely results in case of microscopy inexperience. This study aims to compare the new VIKIA Malaria Ag Pf/Pan™ RDT with PCR-corrected microscopy results and the commonly used CareStart™ RDT to diagnose falciparum and non-falciparum malaria in the endemic setting of Bamako, Mali and the non-endemic setting of Lyon, France.

Methods: Blood samples were collected during a 12-months and six-months period in 2011 from patients suspected to have malaria in Lyon and Bamako respectively. The samples were examined by light microscopy, the VIKIA Malaria Ag Pf/Pan™ test and in Bamako additionally with the CareStart™ RDT. Discordant results were corrected by real-time PCR. Sensitivity, specificity, positive predictive value and negative predictive value were used to evaluate test performance.

Results: Samples of 877 patients from both sites were included. The VIKIA Malaria Ag Pf/Pan™ had a sensitivity of 98% and 96% for Plasmodium falciparum in Lyon and Bamako, respectively, performing similar to PCR-corrected microscopy.

Conclusions: The VIKIA Malaria Ag Pf/Pan™ performs similar to PCR-corrected microscopy for the detection of P. falciparum, making it a valuable tool in malaria endemic and non-endemic regions.

PubMed Disclaimer

References

    1. World Health Organization Global Malaria Programme. World Malaria Report 2012. Geneva: World Health Organization; 2012.
    1. Leslie T, Mikhail A, Mayan I, Anwar M, Bakhtash S, Nader M, Chandler C, Whitty CJ, Rowland M. Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study. BMJ. 2012;345:e4389. doi: 10.1136/bmj.e4389. - DOI - PMC - PubMed
    1. Masaninga F, Sekeseke-Chinyama M, Malambo T, Moonga H, Babaniyi O, Counihan H, Bell D. Finding parasites and finding challenges: improved diagnostic access and trends in reported malaria and anti-malarial drug use in Livingstone district. Zambia. Malar J. 2012;11:341. - PMC - PubMed
    1. Lubell Y, Reyburn H, Mbakilwa H, Mwangi R, Chonya S, Whitty CJ, Mills A. The impact of response to the results of diagnostic tests for malaria: cost-benefit analysis. BMJ. 2008;336:202–205. doi: 10.1136/bmj.39395.696065.47. - DOI - PMC - PubMed
    1. A-Elgayuom SM, El-Feki Ael K, Mahgoub BA, El-Rayahel A, Giha HA. Malaria overdiagnosis and burden of malaria misdiagnosis in the suburbs of central Sudan: special emphasis on artemisinin-based combination therapy era. Diagn Microbiol Infect Dis. 2009;64:20–26. doi: 10.1016/j.diagmicrobio.2009.01.029. - DOI - PubMed

MeSH terms