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Comment
. 2013 Jun 7;112(12):1532-4.
doi: 10.1161/CIRCRESAHA.113.301519.

Build a braveheart: the missing linc (RNA)

Masaharu Kataoka  1 , Zhan-Peng Huang, Da-Zhi Wang
Affiliations
Comment

Build a braveheart: the missing linc (RNA)

Masaharu Kataoka et al. Circ Res. .

Abstract

A novel long non-coding RNA (lncRNA), Braveheart (Bvht), has been defined as a critical regulator of commitment of the embryonic stem cells (ESCs) to cardiovascular lineages. Bvht activates a cardiovascular gene network and functions upstream of mesoderm posterior 1 (MESP1), a master regulator of a common multipotent cardiovascular progenitor. Bvht mediates epigenetic regulation of commitment to a cardiac lineage by interacting with SUZ12, a component of polycomb repressive complex 2 (PRC2). Bvht represents the first lncRNA that defines cardiac cell fate and lineage specificity, linking lncRNAs to cardiac development and disease.

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