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. 2013 Jul;122(1):41-49.
doi: 10.1097/AOG.0b013e318297f37f.

Cerebral palsy and perinatal infection in children born at term

Kristina Ahlin  1 , Kate Himmelmann, Gudrun Hagberg, Marian Kacerovsky, Teresa Cobo, Ulla-Britt Wennerholm, Bo Jacobsson
Affiliations

Cerebral palsy and perinatal infection in children born at term

Kristina Ahlin et al. Obstet Gynecol. 2013 Jul.

Abstract

Objective: To investigate the link between infection-related risk factors for cerebral palsy subtypes in children born at term.

Methods: A case-control study was performed in a population-based series of children with cerebral palsy born at term (n=309) matched with a control group (n=618). The cases were divided into cerebral palsy subtypes: spastic hemiplegia, spastic diplegia, spastic tetraplegia, and dyskinetic cerebral palsy. All forms of spastic cerebral palsy were also analyzed together. All records were examined for maternal and neonatal signs of infection. Univariate and adjusted analyses were performed.

Results: Infection-related risk factors were shown to be independent risk factors for spastic cerebral palsy in the adjusted analyses. This was especially pronounced in the subgroup with spastic hemiplegia in which bacterial growth in urine during pregnancy (n=11 [7.5%], odds ratio [OR] 4.7, 95% confidence interval [CI] 1.5-15.2), any infectious disease during pregnancy (n=57 [39.0%], OR 2.9, 95% CI 1.7-4.8), severe infection during pregnancy (n=12 [8.2%], OR 15.4, 95% CI 3.0-78.1), antibiotic therapy once during pregnancy (n=33 [22.6%], OR 6.3, 95% CI 3.0-15.2) as well as several times during pregnancy (n=9 [6.2%], OR 15.6, 95% CI 1.8-134.2) constituted strong independent risk factors. However, only neonatal infection (n=11 [9.1%], OR 14.7, 95% CI 1.7-126.5) was independently significantly associated with an increased risk of spastic diplegia and tetraplegia.

Conclusions: Infection-related factors are strong independent risk factors for the subgroup with spastic hemiplegia in children with cerebral palsy born at term. The finding is less pronounced in the subgroups with spastic diplegia or tetraplegia.

Level of evidence: II.

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References

    1. Blair E, Watson L. Epidemiology of cerebral palsy. Semin Fetal Neonatal Med 2006;11:117–25.
    1. Himmelmann K, Hagberg G, Uvebrant P. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birth-year period 1999–2002. Acta Paediatr 2010;99:1337–43.
    1. Surveillance of Cerebral Palsy in Europe. Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Surveillance of Cerebral Palsy in Europe (SCPE). Dev Med Child Neurol 2000;42:816–24.
    1. Hagberg B, Hagberg G, Beckung E, Uvebrant P. Changing panorama of cerebral palsy in Sweden. VIII. Prevalence and origin in the birth year period 1991–94. Acta Paediatr 2001;90:271–7.
    1. Keogh JM, Badawi N. The origins of cerebral palsy. Curr Opin Neurol 2006;19:129–34.

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