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Review
. 2013;18(4):127-33.
doi: 10.1179/1351000213Y.0000000050. Epub 2013 Jun 5.

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

Fatma Ucar  1 , Sevilay Sezer, Serpil Erdogan, Sumeyya Akyol, Ferah Armutcu, Omer Akyol
Affiliations
Review

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

Fatma Ucar et al. Redox Rep. 2013.

Abstract

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the most common underlying causes of chronic liver injury. They are associated with a wide spectrum of hepatic disorders including basic steatosis, steatohepatitis, and cirrhosis. The molecular and cellular mechanisms underlying hepatic injury in NAFLD and NASH are still unknown. This review describes the roles of oxidative stress and inflammatory responses in the pathogenesis of NAFLD and its progression to NASH.

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Figures

Figure 1.
Figure 1.
Basic mechanistic model associated with oxidative stress in the pathogenesis of NAFLD and progression to NASH.
See this image and copyright information in PMC

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