Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep;63(5):333-43.
doi: 10.1007/s12576-013-0269-4. Epub 2013 Jun 7.

Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men

Ewa Ziemann  1 , Robert A Olek, Tomasz Grzywacz, Jędrzej Antosiewicz, Sylwester Kujach, Marcin Łuszczyk, Mirosław Smaruj, Ewelina Sledziewska, Radosław Laskowski
Affiliations

Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men

Ewa Ziemann et al. J Physiol Sci. 2013 Sep.

Abstract

This study was aimed to evaluate anti-inflammatory effect of the whole body cryostimulation in obese men. Fourteen subjects (BMI >30 kg m(-2)), divided into two subgroups according to cardiorespiratory fitness: higher (HCF) or lower (LCF), have been exposed to 10 sessions in a cryogenic chamber (-110 °C). Blood samples were collected before, 30 min and 24 h after the first, fifth and last cryostimulation. Coldness exposures affected blood cytokine profile; however, the response depended on subjects' fitness capacity. Concentrations of pro-inflammatory cytokines in the LCF decreased by 19, 6.8, and 7.4 % in IL-6, resistin, and visfatin, respectively. TNFα in the LCF dropped 4.3-fold compared to baseline, while in the HCF, changes were smaller, yet significant. Anti-inflammatory cytokine IL-10 increased in both groups. No changes in adiponectin and leptin were observed in either group. Obtained results suggest that whole body cryostimulation can be a supplementary method for obese in reducing systemic inflammation.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest occurs.

Figures

Fig. 1
Fig. 1
The study design
Fig. 2
Fig. 2
Changes in TNFα concentration in HCF and LCF group during the whole exposure period, *significantly different from HCF group: p < 0.05 for post hoc analysis
See this image and copyright information in PMC

References

    1. von Ruesten A, Steffen A, Floegel A, van der AD, Masala G, Tjonneland A, Halkjaer J, Palli D, Wareham NJ, Loos RJ, Sorensen TI, Boeing H (2011) Trend in Obesity Prevalence in European Adult Cohort Populations during Follow-up since 1996 and Their Predictions to 2015. PLoS ONE 6: e27455 - PMC - PubMed
    1. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6:772–783. doi: 10.1038/nri1937. - DOI - PubMed
    1. Garaulet M, Ordovas JM, Madrid JA. The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond) 2010;34:1667–1683. doi: 10.1038/ijo.2010.118. - DOI - PMC - PubMed
    1. Sood A. Obesity, adipokines, and lung disease. J Appl Physiol. 2010;108:744–753. doi: 10.1152/japplphysiol.00838.2009. - DOI - PMC - PubMed
    1. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116:1494–1505. doi: 10.1172/JCI26498. - DOI - PMC - PubMed

Publication types