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Meta-Analysis
. 2013 Jun 6;2013(6):CD009518.
doi: 10.1002/14651858.CD009518.pub2.

Isoflavones for hypercholesterolaemia in adults

Yu Qin  1 , Kai Niu, Yuan Zeng, Peng Liu, Long Yi, Ting Zhang, Qian Yong Zhang, Jun Dong Zhu, Man Tian Mi
Affiliations
Meta-Analysis

Isoflavones for hypercholesterolaemia in adults

Yu Qin et al. Cochrane Database Syst Rev. .

Abstract

Background: Hypercholesterolaemia is a significant risk factor for cardiovascular diseases. Isoflavones may be effective in improving hypercholesterolaemia.

Objectives: To assess the effects of isoflavones for hypercholesterolaemia.

Search methods: We searched the following databases: The Cochrane Library (Issue 9, 2012), MEDLINE, EMBASE, Chinese BioMedical Database and China National Knowledge Infrastructure (all to September 2012).

Selection criteria: We considered randomized controlled clinical trials in hypercholesterolaemic participants comparing isoflavones versus placebo, or soy isolated protein added with isoflavones versus soy isolated protein alone.

Data collection and analysis: Two review authors independently abstracted relevant population and intervention characteristics. We resolved any disagreements through discussion, or if required by a third party. We assessed the risk of bias of trials against key criteria: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting and other sources of bias.

Main results: We included five randomized trials (208 participants, 104 in the intervention group and 104 in the control group). Interventions ranged from three to six months. Four trials reported results in non-Asian populations published in English. One trial reported results in Chinese people published in Chinese. Overall, the risk of bias of included trials was high or unclear. There were no outcome data on death from any cause, morbidity, complications, health-related quality of life and costs. Two trials reported adverse effects, including gastrointestinal discomfort (bloating and constipation) and an increased number of hot flushes. None of the trials found serious adverse events. There was a slight significant effect on triglycerides in favour of isoflavones when compared with placebo (mean difference (MD) -0.46 mmol/L (95% confidence interval (CI) -0.84 to -0.09; P = 0.02; 52 participants; 2 trials). No statistically significant effects on total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were shown in favour of isoflavones.

Authors' conclusions: We found no evidence for effects of isoflavones on patient-important outcomes or lowering of cholesterol levels in people with hypercholesterolaemia. Our findings have to be interpreted with caution due to high or unclear risk of bias in several risk of bias domains, and low number of participants in trials.

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Conflict of interest statement

None known.

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
4
4
Forest plot of comparison: 1 Isoflavones versus placebo, outcome: 1.1 LDL‐cholesterol [mmol/L].
5
5
Forest plot of comparison: 1 Isoflavones versus placebo, outcome: 1.2 Total cholesterol [mmol/L].
6
6
Forest plot of comparison: 1 Isoflavones versus placebo, outcome: 1.4 Triglycerides [mmol/L].
1.1
1.1. Analysis
Comparison 1 Isoflavones versus placebo or soy protein+isoflavones versus soy protein, Outcome 1 LDL‐cholesterol.
1.2
1.2. Analysis
Comparison 1 Isoflavones versus placebo or soy protein+isoflavones versus soy protein, Outcome 2 Total cholesterol.
1.3
1.3. Analysis
Comparison 1 Isoflavones versus placebo or soy protein+isoflavones versus soy protein, Outcome 3 HDL‐cholesterol.
1.4
1.4. Analysis
Comparison 1 Isoflavones versus placebo or soy protein+isoflavones versus soy protein, Outcome 4 Triglycerides.
1.5
1.5. Analysis
Comparison 1 Isoflavones versus placebo or soy protein+isoflavones versus soy protein, Outcome 5 Sex hormone binding globulin.
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  • doi: 10.1002/14651858.CD009518

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