Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Jun 7;340(6137):1174-5.
doi: 10.1126/science.1239652.

Neuroscience. Illuminating the neural circuitry of compulsive behaviors

Scott L Rauch  1 , William A Carlezon Jr
Affiliations
Comment

Neuroscience. Illuminating the neural circuitry of compulsive behaviors

Scott L Rauch et al. Science. .

Abstract

In this issue, two ground-breaking reports describe the use of optogenetics to control a brain circuit that drives repetitive behavior, opening up new possibilities for the treatment of compulsive disorders.

PubMed Disclaimer

Figures

Fig. 1:
Fig. 1:
Putative roles of orbital frontal cortex (OFC) and ventral medial striatum (VMS) circuits in regulation of repetitive behaviors. Repeated optogenetic stimulation that activates the OFC-VMS pathway (Green) can produce repetitive behaviors (“+”) in wild-type mice, presumably by elevating activity of medium spiny neurons (MSNs; Orange) and triggering neuroadaptations. Sapap3-mutant mice have high levels of repetitive behavior and deficits in repression of MSN activity, both of which are normalized (“−“) by optogenetic stimulation that activates fast-spiking interneurons (FSIs; Red). Dashed lines depict downstream elements of circuits implicated in OCD.
See this image and copyright information in PMC

Comment on

References

    1. Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Deisseroth K, Gordon J, Hen R. Repeated Cortico-Striatal Stimulation Generates Persistent OCD-like Behavior. Science, this issue. - PMC - PubMed
    1. Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. Science, this issue. - PMC - PubMed
    1. Tye KM, Deisseroth K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci 13, 251 (2012). - PMC - PubMed
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed., text rev). Washington, DC (2000).
    1. Morris SE, Cuthbert BN. Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior. Dialogues Clin Neurosci 14, 29 (2012). - PMC - PubMed

Publication types

MeSH terms

Substances