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Comparative Study
. 1990 Jul 19;346(6281):245-50.
doi: 10.1038/346245a0.

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

J Gubbay  1 , J Collignon, P Koopman, B Capel, A Economou, A Münsterberg, N Vivian, P Goodfellow, R Lovell-Badge
Affiliations
Comparative Study

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

J Gubbay et al. Nature. .

Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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