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. 1975 Mar;7(3):281-4.
doi: 10.1128/AAC.7.3.281.

Activity of pure streptovaricins and fractionated streptovaricin complex against Friend virus

J S Horoszewicz, K L Rinehart Jr, S S Leong, W A Carter

Activity of pure streptovaricins and fractionated streptovaricin complex against Friend virus

J S Horoszewicz et al. Antimicrob Agents Chemother. 1975 Mar.

Abstract

Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individual intact streptovaricins (A through G and J) show at least a 30-fold reduction in antiviral activity. These results further support the conclusion that the diversified biological properties of streptovaricin complex probably reside in different molecular structures.

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References

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