Bacterial transcription: Finding the magic spot on RNAP

Comment

Christina Tobin Kåhrström. Nat Rev Microbiol. 2013 Jul.

. 2013 Jul;11(7):429.

doi: 10.1038/nrmicro3053. Epub 2013 Jun 10.

No abstract available

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Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Mechold U, Potrykus K, Murphy H, Murakami KS, Cashel M. Mechold U, et al. Nucleic Acids Res. 2013 Jul;41(12):6175-89. doi: 10.1093/nar/gkt302. Epub 2013 Apr 25. Nucleic Acids Res. 2013. PMID: 23620295 Free PMC article.
The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation.
Ross W, Vrentas CE, Sanchez-Vazquez P, Gaal T, Gourse RL. Ross W, et al. Mol Cell. 2013 May 9;50(3):420-9. doi: 10.1016/j.molcel.2013.03.021. Epub 2013 Apr 25. Mol Cell. 2013. PMID: 23623682 Free PMC article.
The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Zuo Y, Wang Y, Steitz TA. Zuo Y, et al. Mol Cell. 2013 May 9;50(3):430-6. doi: 10.1016/j.molcel.2013.03.020. Epub 2013 Apr 25. Mol Cell. 2013. PMID: 23623685 Free PMC article.