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. 2013 Aug 21;138(16):4574-8.
doi: 10.1039/c3an00447c. Epub 2013 Jun 10.

Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction

Li Li  1 , Tanya Hutter, Ullrich Steiner, Sumeet Mahajan
Affiliations

Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction

Li Li et al. Analyst. .

Abstract

Using the bianalyte method we unambiguously demonstrate that a single gold nanosphere on a metal film junction, in the so-called nanoparticle on a mirror configuration, is capable of single molecule detection with surface-enhanced Raman spectroscopy (SERS). Also this configuration serves as a convenient and highly sensitive SERS sensor for detection of biomolecules. Such simple nano-junction based systems are ideal for chemical and biomedical analysis.

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