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. 2013 Mar 1;6(2):e23001.
doi: 10.4161/cib.23001.

The ubiquitin-proteasome system regulates chloroplast biogenesis

Weihua Huang  1 , Qihua Ling, Paul Jarvis
Affiliations

The ubiquitin-proteasome system regulates chloroplast biogenesis

Weihua Huang et al. Commun Integr Biol. .

Abstract

In a recently published work, we identified the first chloroplast-localized E3 ligase, and showed that it degrades TOC translocon proteins by the ubiquitin-proteasome system (UPS). This regulation was found to be critical for plastid developmental transitions, such as the conversion of etioplasts to chloroplasts. Here we discuss the importance of SP1 for plants under different circumstances, and speculate about SP1 function and its possible application in agriculture. We anticipate that further work in this area may reveal additional roles of the UPS system, through action on other chloroplast OEPs with different roles in plastid biogenesis and function.

Keywords: Arabidopsis thaliana; E3 ligase; SP1; TOC translocon; chloroplast; outer envelope protein (OEP); ubiquitin-proteasome system (UPS).

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References

    1. Moon J, Parry G, Estelle M. The ubiquitin-proteasome pathway and plant development. Plant Cell. 2004;16:3181–95. doi: 10.1105/tpc.104.161220. - DOI - PMC - PubMed
    1. Vierstra RD. The ubiquitin-26S proteasome system at the nexus of plant biology. Nat Rev Mol Cell Biol. 2009;10:385–97. doi: 10.1038/nrm2688. - DOI - PubMed
    1. Jarvis P. Organellar proteomics: chloroplasts in the spotlight. Curr Biol. 2004;14:R317–9. doi: 10.1016/j.cub.2004.03.054. - DOI - PubMed
    1. Jarvis P. Targeting of nucleus-encoded proteins to chloroplasts in plants. New Phytol. 2008;179:257–85. doi: 10.1111/j.1469-8137.2008.02452.x. - DOI - PubMed
    1. Ling Q, Huang W, Baldwin A, Jarvis P. Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Science. 2012;338:655–9. doi: 10.1126/science.1225053. - DOI - PubMed

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