Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2013 Jul;20(7):855-7.
doi: 10.1038/cdd.2013.53.

Not all p53 gain-of-function mutants are created equal

S S Mello, L D Attardi
Editorial

Not all p53 gain-of-function mutants are created equal

S S Mello et al. Cell Death Differ. 2013 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
In vivo gain-of-function (GOF) phenotypes of p53 point mutant mouse strains (mut/− or mut/mut) relative to p53−/− mice. (a) Summary of p53 GOF effects in different knock-in mutant mouse strains, both those previously published and those described by Hanel et al., including mouse mutants and HUPKI mutants. We have emphasized those studies in which there was no wild-type p53 allele present, to rule out any dominant-negative effects of mutant p53 on wild-type p53. Whether there is a broader tumor spectrum or decreased survival compared with p53−/− mice is indicated. Novel tumors developing in the mutant/− strains relative to p53−/− mice, which develop thymic lymphomas and sarcomas, are indicated. (b) Summary of key phenotypes in p53R248Q/− and p53G245S/− mice. Increased Akt signaling is observed in p53R248Q/− and p53G245S/− lymphomas relative to those in p53−/− mice, suggesting that this enhanced signaling could generally account for p53 GOF phenotypes. In contrast, only p53R248Q/− mice display higher proliferation rates in lymphomas and an expansion of hematopoietic and mesenchymal stem cell populations relative to p53−/− mice, culminating in a particularly dramatic GOF phenotype
See this image and copyright information in PMC

Comment on

References

    1. Brady CA, Attardi LD. J Cell Sci. 2010. pp. 2527–2532. - PMC - PubMed
    1. Beckerman R, Prives C. Cold Spring Harbor Perspect Biol. 2010. p. a000935. - PMC - PubMed
    1. Petitjean A, et al. Hum Mut. 2007. pp. 622–629. - PubMed
    1. Brosh R, Rotter V. Nat Rev Cancer. 2009. pp. 701–713. - PubMed
    1. Dittmer D, et al. Nat Genet. 1993. pp. 42–46. - PubMed

Publication types

MeSH terms

Substances