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. 1990 Jul 20;249(4966):296-8.
doi: 10.1126/science.2374928.

Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor

G Todderud  1 , M I Wahl, S G Rhee, G Carpenter
Affiliations

Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor

G Todderud et al. Science. .

Abstract

Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.

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