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Case Reports
. 2013 Jun 6:2013:bcr2013010001.
doi: 10.1136/bcr-2013-010001.

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

Wan Faiziah Wan Abdul Rahman  1 , Mohd Nizam Md Hashim, Thin Thin Win, Ikmal Hisyam Bakrin
Affiliations
Case Reports

Solid variant of papillary thyroid carcinoma in a 14-year-old girl

Wan Faiziah Wan Abdul Rahman et al. BMJ Case Rep. .

Abstract

Solid variant of papillary thyroid carcinoma (PTC) is a rare, poorly characterised variant and predominantly reported in children with a history of radiation exposure. This variant has a high propensity for extra-thyroidal extension and cervical lymph node metastases. A 14-year-old Malay girl who had no history of radiation exposure, presented with multiple cervical lymphadenopathy and it was clinically suspicious for tuberculosis or lymphoma. An incisional biopsy revealed a metastatic PTC. The patient underwent total thyroidectomy with bilateral lateral neck dissection and histopathology report was solid variant of PTC. Whole-body I(131) scan was performed which revealed an intense tracer uptake in the neck. She was planned for radioactive iodine ablation and now on regular follow-up for monitoring of possible tumour metastasis.

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Figures

Figure 1
Figure 1
Solid variant of papillary thyroid carcinoma. Note the solid nests surrounded by delicate fibrohyaline stroma. No papillary growth is present (H&E staining ×10).
Figure 2
Figure 2
Solid variant of papillary thyroid carcinoma (PTC). At higher magnification note the classical nuclear features of PTC; nuclear clearing,intranuclear cytoplasmic inclusions, nuclear grooves and abundant pale eosinophilic cytoplasm with distinct borders (H&E staining ×40).
Figure 3
Figure 3
Vascular invasion by solid variant of papillary thyroid carcinoma (H&E staining ×20).
Figure 4
Figure 4
A psammoma body in solid variant of papillary thyroid carcinoma, characterised by laminated, concentric calcification (H&E staining ×20).
Figure 5
Figure 5
Solid variant of papillary thyroid carcinoma with nuclear positivity for thyroid transcription factor-1 (×20).
See this image and copyright information in PMC

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