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. 2010 Feb;1(1):35-41.
doi: 10.1017/S2040174409990055.

Maternal predictors of neonatal bone size and geometry: the Southampton Women's Survey

N C Harvey  1 , M K Javaid  1 , N K Arden  1 , J R Poole  1 , S R Crozier  1 , S M Robinson  1 , H M Inskip  1 , K M Godfrey  1 , E M Dennison  1 , C Cooper  1 ; SWS Study Team
Affiliations

Maternal predictors of neonatal bone size and geometry: the Southampton Women's Survey

N C Harvey et al. J Dev Orig Health Dis. 2010 Feb.

Abstract

Early growth is associated with later risk of osteoporosis and fractures. In this study, we aimed to evaluate the relationships between maternal lifestyle and body composition and neonatal bone size, geometry and density in the offspring. Participants were recruited from the Southampton Women's Survey, a unique prospective cohort of 12,500 initially non-pregnant women aged 20-34 years, resident in Southampton, UK. These women were studied in detail before and during pregnancy, and the offspring underwent anthropometric and bone mineral assessment (using dual energy-X-ray absorptiometry) at birth. A total of 841 mother-baby pairs were studied (443 boys and 398 girls). The independent predictors of greater neonatal whole body bone area (BA) and bone mineral content included greater maternal birthweight, height, parity, triceps skinfold thickness and lower walking speed in late pregnancy. Maternal smoking was independently associated with lower neonatal bone mass. Neonatal BA adjusted for birth length (a measure of bone width) was predicted positively by maternal parity and late pregnancy triceps skinfold thickness and negatively by late pregnancy walking speed. These findings were similar in both genders. We have confirmed, in a large cohort, previous findings that maternal lifestyle and body build predict neonatal bone mineral; additionally, maternal parity and fat stores and walking speed in late pregnancy were associated with neonatal bone geometry. These findings may suggest novel public health strategies to reduce the burden of osteoporotic fracture in future generations.

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Figures

Fig. 1
Fig. 1
Maternal determinants of neonatal bone area (BA) and bone mineral content (BMC).
Fig. 2
Fig. 2
Maternal predictors of neonatal bone area (BA) and bone mineral content (BMC) adjusted for birth length.
See this image and copyright information in PMC

References

    1. Hernandez CJ, Beaupre GS, Carter DR. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int. 2003;14:843–847. - PubMed
    1. Cooper C, Cawley M, Bhalla A, et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995;10:940–947. - PubMed
    1. Dennison EM, Aihie-Sayer A, Syddall H, et al. Birthweight is associated with bone mass in the seventh decade: the Hertfordshire 31–39 Study. Pediatr Res. 2005;57:582–586. - PubMed
    1. Cooper C, Eriksson JG, Forsen T, et al. Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporos Int. 2001;12:623–629. - PubMed
    1. Godfrey K, Walker-Bone K, Robinson S, et al. Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res. 2001;16:1694–1703. - PubMed