Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu
- PMID: 23750643
- PMCID: PMC3787720
- DOI: 10.2217/epi.13.24
Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu
Abstract
Aim: We examined the association between birth weight and methylation in the imprinted IGF/H19 loci, the nonimprinted gene NR3C1 and repetitive element DNA (LINE-1 and Alu).
Materials & methods: We collected umbilical cord venous blood from 219 infants born in Mexico City (Mexico) as part of a prospective birth cohort study and analyzed DNA methylation using pyrosequencing.
Results: Birth weight was not associated with DNA methylation of the regions studied. One of the CpG dinucleotides in the IGF2 imprinting control region (ICR)1 includes a potential C-T SNP. Among individuals with an absence of methylation at this site, probably due to a paternally inherited T allele, birth weight was associated with mean methylation status of both IGF2 ICR1 and ICR2. However, this association would not have survived adjustment for multiple testing.
Conclusion: While we did not detect an association between DNA methylation and birth weight, our study suggests a potential gene-epigene interaction between a T allele in the IGF2 ICR1 and methylation of ICRs of IGF2, and fetal growth.
Figures



References
-
- Brodsky D, Christou H. Current concepts in intrauterine growth restriction. J Intensive Care Med. 2004;19(6):307–319. - PubMed
-
- Horike S, Ferreira JC, Meguro-Horike M, et al. Screening of DNA methylation at the H19 promoter or the distal region of its ICR1 ensures efficient detection of chromosome 11p15 epimutations in Russell–Silver syndrome. Am J Med Genet A. 2009;149A(11):2415–2423. - PubMed
Website
-
- Mayo Clinic. [Accessed 1 February 2012];Beckwith–Wiedemann syndrome (BWS)/Russell–Silver syndrome (RSS) molecular analysis. www.mayomedicallaboratories.com/test-catalog/Specimen/61010.
Publication types
MeSH terms
Substances
Grants and funding
- T32ES007069/ES/NIEHS NIH HHS/United States
- R00 ES020346/ES/NIEHS NIH HHS/United States
- R01ES013744/ES/NIEHS NIH HHS/United States
- R01 ES014930/ES/NIEHS NIH HHS/United States
- R01ES014930/ES/NIEHS NIH HHS/United States
- T32 ES007069/ES/NIEHS NIH HHS/United States
- K99 ES020346/ES/NIEHS NIH HHS/United States
- P42 ES016454/ES/NIEHS NIH HHS/United States
- R01 ES020268/ES/NIEHS NIH HHS/United States
- K99ES020346/ES/NIEHS NIH HHS/United States
- P42ES016454/ES/NIEHS NIH HHS/United States
- Y01 ES000001/ES/NIEHS NIH HHS/United States
- R01 ES013744/ES/NIEHS NIH HHS/United States
- R01ES000001/ES/NIEHS NIH HHS/United States
- R01ES020268/ES/NIEHS NIH HHS/United States
- K23ES022242/ES/NIEHS NIH HHS/United States
- K23 ES022242/ES/NIEHS NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous