Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry

Abstract

Isocyanides have been important building blocks in organic synthesis since the discovery of the Ugi reaction and related isocyanide-based multicomponent reactions. In the past decade isocyanides have found a new application as versatile C1 building blocks in palladium catalysis. Palladium-catalyzed reactions involving isocyanide insertion offer a vast potential for the synthesis of nitrogen-containing fine chemicals. This Minireview discusses all the achievements in this emerging field.

Keywords: heterocycles; homogeneous catalysis; isocyanides; palladium; synthetic methods.