Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Nov 8:4:79-82.
doi: 10.2147/IMCRJ.S26102. Print 2011.

Effectiveness of a combination of cyclosporine A, suplatast tosilate and prednisolone on periodic oscillating hypereosinophilia

Shinsaku Imashuku  1 , Ikuyo Ueda, Tohru Inaba
Affiliations
Case Reports

Effectiveness of a combination of cyclosporine A, suplatast tosilate and prednisolone on periodic oscillating hypereosinophilia

Shinsaku Imashuku et al. Int Med Case Rep J. .

Abstract

We report the treatment course of a 29-year-old man who has had unique oscillating FIP1L1-PDGFRA fusion gene-negative hypereosinophilic syndrome (HES) for nearly 6 years. His periodic oscillating pattern of eosinophilia associated with angioedematous soft tissue swelling has shown two to three seasonal peaks (>15,000/μL absolute eosinophil counts [AEC]) a year. Initially, the patient, who was thought to have distinct HES not compatible with previously described cases, did not respond to treatment except for a temporary response to imatinib mesylate. For 6 years, from 2005 to 2010, he was treated with a combination of oral cyclosporine A, suplatast tosilate, and a small dose of prednisolone, which significantly reduced the peak heights of AEC as well as blunting the oscillating patterns.

Keywords: IgM; angioedema; cyclosporin A; eosinophilia; hypereosinophilic syndrome; sIL-2R; suplatast tosilate; treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Monthly oscillation of absolute eosinophil counts (AEC) in the patient. Peaks of AEC are seen to be significantly reduced from 2005 to 2007 (A), and from 2008 to 2010 (B). Note: Numbers in the abscissa indicate months from January to December.
Figure 2
Figure 2
Correlation between absolute neutrophil counts (AEC) and serum IgM levels.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Gleich GJ, Leiferman KM. The hypereosinophilic syndromes: still more heterogeneity. Curr Opin Immunol. 2005;17(6):679–684. - PubMed
    1. Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348(13):1201–1214. - PubMed
    1. Pardanani A, Brockman SR, Paternoster SF, et al. FIP1L1-PDGFRA fusion: Prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. 2004;104(10):3038–3045. - PubMed
    1. Xiao Z, Hao Y, Qin T, Han Z. Periodic oscillation of blood leukocytes, platelets, and hemoglobin in a patient with chronic eosinophilic leukemia. Leukemia Res. 2003;27:89–91. - PubMed
    1. Malcovati L, la Starza R, Merante S, Pietra D, Mecucci C, Cazzola M. Hypereosinophilic syndrome and cyclic oscillations in blood cell counts. A clonal disorder of hematopoiesis originating in a pluripotent stem cell. Haematologica. 2004;89(4):497–499. - PubMed

Publication types