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. 2013 Sep-Oct;54(5):428-36.
doi: 10.1016/j.psym.2013.02.015. Epub 2013 Jun 4.

Depression and death in diabetes; 10-year follow-up of all-cause and cause-specific mortality in a diabetic cohort

Shane M Coleman  1 , Wayne Katon, Elizabeth Lin, Michael Von Korff
Affiliations

Depression and death in diabetes; 10-year follow-up of all-cause and cause-specific mortality in a diabetic cohort

Shane M Coleman et al. Psychosomatics. 2013 Sep-Oct.

Abstract

Background: When depression co-occurs with type 2 diabetes, adverse bidirectional interactions increase the burden of both illnesses. In addition to affecting patient's health, functioning, and quality of life, this relationship also results in increased mortality compared with those with depression or diabetes alone.

Objective: The purpose of this study was to examine the relationship between depression and all-cause as well as cause-specific mortality in patients with type 2 diabetes by extending findings from our 5-year mortality study. Specifically, we re-examined the risk of depression and all-cause, cardiovascular, cancer, and non-cardiovascular, non-cancer related deaths.

Method: We used an ICD-10 algorithm combined with death certificate data to classify mortality types among type 2 diabetic patients who participated in the Pathways Epidemiologic Study. Cox proportional hazard modeling was used to examine the relationships between depression status and mortality over a 10-year period.

Results: We found a significant positive relationship between depression and all-cause as well as non-cardiovascular, non-cancer mortality in this sample (n = 4128). Cardiovascular mortality failed to reach significance in fully adjusted models and, in contrast to the 5-year data, no trend or significant relationship was observed between depression status and cancer related deaths.

Conclusions: Our study confirmed a significant positive relationship between depression and mortality in patients with type 2 diabetes. Major depression demonstrated a stronger relationship than did minor depression, and among cause-specific groups, non-cardiovascular, non-cancer death types demonstrated the largest magnitude of association with depression status.

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Conflict of interest statement

Conflicts of Interest:

Dr. Von Korff receives funding from Pfizer through a sub-contract with Geisinger for research related to low back pain. Dr. Katon has been funded for CME and talks from Lilly, Pfizer, Wyeth and Forest. Drs. Lin and Coleman have no conflicts of interest to report.

Figures

Figure 1
Figure 1
Recruitment of Epidemiologic Cohort Study to Assess Mortality *adapted from the original publication
See this image and copyright information in PMC

References

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