Comment on

• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.

  Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Nakagawa T, et al. Nature. 2000 Jan 6;403(6765):98-103. doi: 10.1038/47513. Nature. 2000. PMID: 10638761
• Plasma cell differentiation requires the transcription factor XBP-1.

  Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Reimold AM, et al. Nature. 2001 Jul 19;412(6844):300-7. doi: 10.1038/35085509. Nature. 2001. PMID: 11460154
• IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

  Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. Calfon M, et al. Nature. 2002 Jan 3;415(6867):92-6. doi: 10.1038/415092a. Nature. 2002. PMID: 11780124