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Editorial
. 2013 Jul 9;128(2):92-4.
doi: 10.1161/CIRCULATIONAHA.113.003869. Epub 2013 Jun 11.

Mechanisms of cell therapy for clinical investigations: an urgent need for large-animal models

Jianyi Jay Zhang
Editorial

Mechanisms of cell therapy for clinical investigations: an urgent need for large-animal models

Jianyi Jay Zhang. Circulation. .
No abstract available

Keywords: Editorials; cells; heart failure; myocardial infarction.

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Figures

Figure 1
Figure 1
Mechanisms of cell therapy for myocardial repair. The therapeutic mechanisms induced by cell transplantation can be grouped into two categories: cardiac regeneration and myocardial protection. Regenerative mechanisms include the transdifferentiation of engrafted CPCs into cardiomyocytes and vascular cells, as well as the release of trophic factors that subsequently activate resident CPCs or stimulate cell-cycle progression and proliferation in native cardiac cells. Trophic factors can also induce cytoprotective mechanisms that impede apoptosis immediately after the infarct event and promote neovascularization, which continues to increase cardiac performance at later time points through the beneficial feedback from improvements in perfusion, metabolism, and LV chamber function.
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References

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