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Comment
. 2013 Jun 15;12(12):1823-4.
doi: 10.4161/cc.25173. Epub 2013 May 30.

MicroRNA-181a/b: novel biomarkers to stratify breast cancer patients for PARPi treatment

Federica Mori  1 , Sabrina Strano, Giovanni Blandino
Affiliations
Comment

MicroRNA-181a/b: novel biomarkers to stratify breast cancer patients for PARPi treatment

Federica Mori et al. Cell Cycle. .
No abstract available

Keywords: breast cancer; dataset; inhibitor; microRNA; mutation; phenotype; treatment.

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Figures

None
Figure 1. Hereditary breast cancers and sporadic breast cancers presenting BRCA1 mutations account for the 12% of the total breast tumors. Basal-like and triple-negative breast cancers among the sporadic breast tumors (88%) that present “BRCAness” phenotype and may be screened for miR-181a/b expression to treat selectively with PARP inhibitor.
See this image and copyright information in PMC

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References

    1. Bisso A, Faleschini M, Zampa F, Capaci V, De Santa J, Santarpia L, et al. Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. Cell Cycle. 2013;12 - PMC - PubMed
    1. Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E, Perez-Plasencia C, Del Moral-Hernandez O, Castaneda-Ortiz EJ, et al. MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis. Int J Mol Sci. 2012;13:1347–79. doi: 10.3390/ijms13021347. - DOI - PMC - PubMed
    1. Neel JC, Lebrun JJ. Activin and TGFβ regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells. Cell Signal. 2013;7:1556–66. doi: 10.1016/j.cellsig.2013.03.013. - DOI - PubMed
    1. Wang Y, Yu Y, Tsuyada A, Ren X, Wu X, Stubblefield K, et al. Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene. 2011;30:1470–80. doi: 10.1038/onc.2010.531. - DOI - PMC - PubMed
    1. Taylor MA, Sossey-Alaoui K, Thompson CL, Danielpour D, Schiemann WP. TGF-β upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest. 2013;123:150–63. doi: 10.1172/JCI64946. - DOI - PMC - PubMed

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