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Review
. 2013 Apr;238(4):344-9.
doi: 10.1177/1535370213477981.

Claudins and gastric carcinogenesis

Omid Iravani  1 , Benjamin Wei-Rong Tay, Pei-Jou Chua, George Wai-Cheong Yip, Boon-Huat Bay
Affiliations
Free article
Review

Claudins and gastric carcinogenesis

Omid Iravani et al. Exp Biol Med (Maywood). 2013 Apr.
Free article

Abstract

Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight junctions. It is now established that CLDNs are differentially altered in gastric cancer and CLDN proteins are believed to play different roles in the growth and progression of gastric cancer.

Keywords: cancer progression; claudin; gastric cancer; tight junction.

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