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Review
. 2013 Jul;13(7):511-8.
doi: 10.1038/nrc3536. Epub 2013 Jun 13.

The evolution of the cancer niche during multistage carcinogenesis

Mary Helen Barcellos-Hoff  1 , David Lyden, Timothy C Wang
Affiliations
Review

The evolution of the cancer niche during multistage carcinogenesis

Mary Helen Barcellos-Hoff et al. Nat Rev Cancer. 2013 Jul.

Abstract

The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.

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