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. 2013 Sep;17(3):479-84.
doi: 10.1093/icvts/ivt222. Epub 2013 Jun 12.

External validity of the Society of Thoracic Surgeons risk stratification tool for deep sternal wound infection after cardiac surgery in a UK population

Bilal H Kirmani  1 , Khurum Mazhar, Hesham Z Saleh, Andrew N Ward, Matthew Shaw, Brian M Fabri, D Mark Pullan
Affiliations

External validity of the Society of Thoracic Surgeons risk stratification tool for deep sternal wound infection after cardiac surgery in a UK population

Bilal H Kirmani et al. Interact Cardiovasc Thorac Surg. 2013 Sep.

Abstract

Objectives: Deep sternal wound infection (DSWI) is a devastating complication of cardiac surgery, with a historical incidence of 0.4-5%. Predicting which patients are at higher risk of infection may help instituting various preventive measures. Risk calculations for mortality have been used as surrogates to estimate the risk of deep sternal wound infection, with limited success. The Society of Thoracic Surgeons (STS) 2008 Risk Calculator modelled the risk of DSWI for cardiac surgical patients, but it has not been validated since its publication. We sought to assess the external validity of the STS-estimated risk of DSWI in a United Kingdom (UK) population.

Methods: Using our prospectively captured database, we retrospectively calculated the risk of DSWI for 14 036 patients undergoing valve, coronary artery bypass grafts or combined procedures between February 2001 and March 2010. DSWI was identified according to the Centre for Disease Control and Prevention definition. The receiver operator characteristic (ROC) curve was employed to test the performance of the model using the area under the ROC curve (AUROC). The calibration of the model was interrogated using the Hosmer-Lemeshow test for Goodness of Fit.

Results: A total of 135 (0.95%) patients developed DSWI. Although there was a statistically significant difference in the calculated risk of patients who contracted DSWI (0.44% ± 0.01) vs those who did not (0.28% ± 0.00, P < 0.0001), the AUROC of 0.699 (95% confidence interval: 0.6522-0.7414) denoted a modest discriminatory power, with the Hosmer-Lemeshow Goodness of Fit statistic (P < 0.001) suggesting poor calibration. A risk-adjusted modifier improved the calibration (P = 0.08).

Conclusions: The STS risk calculator lacks adequate discriminatory power for estimating the isolated risk of developing deep sternal wound infection in a UK population. The discrimination is similar to the tool's validation c-statistic and may have a place in an integrated calculator.

Keywords: Complications; Infection; Risk analysis/modelling; Statistics; Sternum.

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Figures

Figure 1:
Figure 1:
ROC curve for all procedures. AUROC 0.699.
Figure 2:
Figure 2:
Kaplan–Meier survival curves for patients with and without DSWI. Solid line: no DSWI; dotted line: DSWI (P < 0.0001).
Figure 3:
Figure 3:
Observed vs expected mortality proportions derived from Hosmer–Lemeshow groups. Vertical bars and points represent mean and 95% confidence interval (CI) for observed mortality for each group. Oblique line is the expected mortality (Hosmer–Lemeshow Goodness of Fit statistic: P < 0.0001).
Figure 4:
Figure 4:
Observed vs expected mortality proportions with a risk-adjusted modifier applied, derived from Hosmer–Lemeshow groups. Vertical bars and points represent mean and 95% CI for observed mortality for each group. Oblique line is the expected mortality as calculated by the STS with a risk-modified of x4 applied (Hosmer–Lemeshow Goodness of Fit statistic: P = 0.08).
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References

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