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. 2014 Feb;27(1):107-11.
doi: 10.1007/s10334-013-0380-9. Epub 2013 Jun 13.

Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application

Maxim Terekhov  1 , Alexander Scholz, Laura M Schreiber
Affiliations

Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application

Maxim Terekhov et al. MAGMA. 2014 Feb.

Abstract

Object: We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.

Method: The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.

Results: The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.

Conclusion: The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.

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