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Case Reports
. 2013 Apr;4(2):149-51.
doi: 10.4103/0976-500X.110913.

Clozapine associated thrombocytopenia

Natasha Kate  1 , Sandeep Grover, Munish Aggarwal, Pankaj Malhotra, Manupdesh S Sachdeva
Affiliations
Case Reports

Clozapine associated thrombocytopenia

Natasha Kate et al. J Pharmacol Pharmacother. 2013 Apr.

Abstract

Although agranulocytosis as a side effect of clozapine is well known, there is scarcity of data with regard to thrombocytopenia associated with clozapine. In this report we describe a case of clozapine induced thrombocytopenia and review the existing literature. A 22 year old female patient developed thrombocytopenia while on clozapine 187.5 mg/day for 17 weeks. Thrombocytopenia persisted for 24 weeks even after reduction in the dose of clozapine and ultimately clozapine had to be stopped, which led to resolution of thrombocytopenia. Clozapine-induced thrombocytopenia is a less well-known, but potentially serious, adverse effect that should be screened for in practice. The case highlights the fact that besides monitoring the leucocyte count, platelet count of patients receiving clozapine should also be monitored.

Keywords: Clozapine; platelet; thrombocytopenia.

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Conflict of interest statement

Conflict of Interest: None declared.

References

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