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. 2013:2013:828532.
doi: 10.1155/2013/828532. Epub 2013 May 23.

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction

Ewa L Gregoraszczuk  1 , Anna Ptak
Affiliations

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction

Ewa L Gregoraszczuk et al. Int J Endocrinol. 2013.

Abstract

Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause serious reproductive problems, including ovotoxic action, lack of ovulation, premature ovarian failure (POF), or polycystic ovarian syndrome (PCOS). Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. The complexity and diversity of factors belonging to POPs and disorders of the reproductive function of women indicate that the impact of environmental pollution as an important determinant factor in fertility should not be minimize.

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Figures

Figure 1
Figure 1
Generic structure of the (a) DDT, (b) PCBs, (c) PCNs, (d) PCDDs, (e) PCDFs, and (f) PBDEs.
See this image and copyright information in PMC

References

    1. Pocar P, Brevini TAL, Fischer B, Gandolfi F. The impact of endocrine disruptors on oocyte competence. Reproduction. 2003;125(3):313–325. - PubMed
    1. Campagna C, Sirard MA, Ayotte P, Bailey JL. Impaired maturation, fertilization, and embryonic development of porcine oocytes following exposure to an environmentally relevant organochlorine mixture. Biology of Reproduction. 2001;65(2):554–560. - PubMed
    1. Pocar P, Brevini TAL, Perazzoli F, Cillo F, Modina S, Gandolfi F. Cellular and molecular mechanisms mediating the effects of polychlorinated biphenyls on oocyte developmental competence in Cattle. Molecular Reproduction and Development. 2001;60(4):535–541. - PubMed
    1. Campagna C, Guillemette C, Paradis R, Sirard MA, Ayotte P, Bailey JL. An environmentally relevant organochlorine mixture impairs sperm function and embryo development in the porcine model. Biology of Reproduction. 2002;67(1):80–87. - PubMed
    1. Eskenazi B, Warner M, Mocarelli P, et al. Serum dioxin concentrations and menstrual cycle characteristics. American Journal of Epidemiology. 2002;156(4):383–392. - PubMed

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