Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:976810.
doi: 10.1155/2013/976810. Epub 2013 May 20.

Analysis of inflammatory mediators in type 2 diabetes patients

Ahmed Al-Shukaili  1 , Saif Al-Ghafri, Safia Al-Marhoobi, Said Al-Abri, Jawad Al-Lawati, Masoud Al-Maskari
Affiliations

Analysis of inflammatory mediators in type 2 diabetes patients

Ahmed Al-Shukaili et al. Int J Endocrinol. 2013.

Abstract

The main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations. Fifty-seven patients with type-2 diabetes and 30 healthy volunteers were enrolled in this study. Data for the C-reactive protein (CRP), haemoglobin, HbA1c, and autoantibody levels were obtained from the patients files. The cytokine concentrations were measured in patient's serum using commercially available ELISA assays. Lymphocytes subsets were measured by flow cytometric methods. The levels of IL-1β, IL-6, IL-15, and TNF-α were found to be decreased in T2DM patients, whereas the levels of IL-10, IFN-γ, and caspase-1 were increased, compared to normal controls. T2DM patients with hypertension show significantly decreased levels of IL-1β and caspase-1 compared to patients without hypertension. No significant differences in lymphocytes subset between cases and normal control were observed. Significant correlations were found between HbA1c and IL-6; body mass index (BMI) was significantly correlated with CRP, TNF-α, and phosphate; the weight (Wt) was associated with CRP and IFN-γ. In conclusion, an alteration in the function of the immune system was observed in T2DM patient.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Decreased cytokine profile in T2DM.
Figure 2
Figure 2
Increased cytokine profile in T2DM.
Figure 3
Figure 3
Cytokine profile in T2DM with or without hypertension. *Significant difference (P value < 0.05).
See this image and copyright information in PMC

References

    1. Al-Shookri A, Khor GL, Chan YM, Loke SC, Al-Maskari M. Type 2 diabetes in the Sultanate of Oman. Malaysian Journal of Nutrition. 2011;17(1):129–141. - PubMed
    1. Al-Lawati JA, Barakat MN, Al-Maskari M, Elsayed MK, Al-Lawati AM, Mohammed AJ. HbA1c levels among primary healthcare patients with type 2 diabetes mellitus in Oman. Oman Medical Journal. 2012;27(6):465–470. - PMC - PubMed
    1. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia. 1998;41(10):1241–1248. - PubMed
    1. Goyal R, Faizy AF, Siddiqui SS, Singhai M. Evaluation of TNF-α and IL-6 levels in obese and non-obese diabetics: pre- and post-insulin effects. North American Journal of Medical Sciences. 2012;4(4):180–184. - PMC - PubMed
    1. Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. Journal of Lipid Research. 2005;46(11):2347–2355. - PubMed

LinkOut - more resources