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. 2013 Aug;103(8):e34-43.
doi: 10.2105/AJPH.2013.301394. Epub 2013 Jun 13.

Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease

Yunsheng Ma  1 , Raji Balasubramanian, Sherry L Pagoto, Kristin L Schneider, James R Hébert, Lawrence S Phillips, Joseph S Goveas, Annie L Culver, Barbara C Olendzki, James Beck, Jordan W Smoller, Deidre M Sepavich, Judith K Ockene, Lisa Uebelacker, Martha Zorn, Simin Liu
Affiliations

Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease

Yunsheng Ma et al. Am J Public Health. 2013 Aug.

Abstract

Objectives: We investigated whether depressive symptoms and antidepressant use are associated with biomarkers for glucose dysregulation and inflammation, body mass index (BMI), and waist circumference.

Methods: Postmenopausal women were recruited into the Women's Health Initiative from 1993 to 1998, and data were collected at regular intervals through 2005. We used multiple linear regression models to examine whether depressive symptoms and antidepressant use are associated with BMI, waist circumference, and biomarkers.

Results: Analysis of data from 71, 809 women who completed all relevant baseline and year 3 assessments showed that both elevated depressive symptoms and antidepressant use were significantly associated with higher BMI and waist circumference. Among 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance. Analyses of baseline data from 2242 women showed that both elevated depressive symptoms and antidepressant use were associated with higher C-reactive protein levels.

Conclusions: Monitoring body habitus and other biomarkers among women with elevated depression symptoms or taking antidepressant medication may be prudent to prevent diabetes and cardiovascular disease.

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References

    1. Bromberger JT, Kravitz HM. Mood and menopause: findings from the Study of Women’s Health Across the Nation (SWAN) over 10 years. Obstet Gynecol Clin North Am. 2011;38(3):609–625. - PMC - PubMed
    1. Arroyo C, Hu FB, Ryan LM et al. Depressive symptoms and risk of type 2 diabetes in women. Diabetes Care. 2004;27(1):129–133. - PMC - PubMed
    1. Carnethon MR, Biggs ML, Barzilay JI et al. Longitudinal association between depressive symptoms and incident type 2 diabetes mellitus in older adults: the Cardiovascular Health Study. Arch Intern Med. 2007;167(8):802–807. - PubMed
    1. Everson-Rose SA, Meyer PM, Powell LH et al. Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care. 2004;27(12):2856–2862. - PubMed
    1. Golden SH, Williams JE, Ford DE et al. Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes Care. 2004;27(2):429–435. - PubMed

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