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Comment
. 2013 Jun 10;23(6):713-5.
doi: 10.1016/j.ccr.2013.05.012.

Adaptation to starvation: translating a matter of life or death

Brendan D Manning  1
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Free article
Comment

Adaptation to starvation: translating a matter of life or death

Brendan D Manning. Cancer Cell. .
Free article

Abstract

There is much interest in defining the nutrient dependencies of cancer cells and their mechanisms of adaptation to nutrient depletion. In a recent issue of Cell, Leprivier and colleagues demonstrate that eEF2K, which can inhibit translation elongation acutely during protein synthesis, is a critical switch in the survival versus death fate of starved cancer cells.

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  • The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
    Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH. Leprivier G, et al. Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055. Cell. 2013. PMID: 23706743 Free PMC article.

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