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Comment
. 2013 Jun 10;23(6):715-7.
doi: 10.1016/j.ccr.2013.05.017.

Mind the IQGAP

Berta Sanchez-Laorden  1 , Amaya Viros, Richard Marais
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Free article
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Mind the IQGAP

Berta Sanchez-Laorden et al. Cancer Cell. .
Free article

Abstract

The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.

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