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. 2013 Sep-Oct;12(5):325-33.
doi: 10.1177/2325957413491432.

Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy

Katherine Krauskopf, Mark L Van Natta, Ronald P Danis, Sapna Gangaputra, Lori Ackatz, Adrienne Addessi, Alex D Federman, Andrea D Branch, Curtis L Meinert, Douglas A Jabs; Studies of the Ocular Complications of AIDS Research Group

Correlates of hypertension in patients with AIDS in the era of highly active antiretroviral therapy

Katherine Krauskopf et al. J Int Assoc Provid AIDS Care. 2013 Sep-Oct.

Abstract

Background: It is unclear whether HIV-related factors modify risk of hypertension (HTN). In a cohort of patients with AIDS, the authors determined HTN incidence and prevalence and assessed associated traditional, HIV-specific, and retinal vasculature factors.

Methods: Prospective observational cohort included 2390 patients with AIDS (1998-2011). Univariate analysis was used to assess the impact of traditional- and AIDS-related risk factors for HTN prevalence and incidence. Multivariate regression analyses were used to evaluate the adjusted impact of these factors.

Results: Hypertension prevalence was 22%(95% confidence interval [CI] 21%-24%) and was associated with traditional HTN risk factors (age, black race, and higher weight) as well as diabetes, hyperlipidemia, time since AIDS diagnosis, and higher CD4 counts. Hypertension incidence was 64.1 per 1000 person-years (95% CI 58.7/1000-69.9/1000). Age, race, weight, and diabetes were associated with incident HTN but HIV-specific factors were not.

Conclusions: Hypertension, a prevalent cardiovascular risk factor in patients with AIDS, is associated with traditional and metabolic risk factors.

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Conflict of interest statement

Conflict of Interest: Dr. Jabs has been a consultant to Abbott Pharmaceuticals, Alcon Laboratories, Allergan, Inc., Corcept Therapeutics, Genentech, Genzyme Corporation, GlaxoSmithKline, and Roche Pharmaceuticals, and serves on Data and Safety Monitoring Committees for Applied Genetic Technologies Corporation and Novartis Pharmaceutical Corporation. The remaining authors have no conflicts of interest to declare.

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