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Review
. 2013 Jul;13(7):510-8.
doi: 10.1038/nri3465. Epub 2013 Jun 14.

On guard: coronin proteins in innate and adaptive immunity

Jean Pieters  1 , Philipp Müller, Rajesh Jayachandran
Affiliations
Review

On guard: coronin proteins in innate and adaptive immunity

Jean Pieters et al. Nat Rev Immunol. 2013 Jul.

Abstract

Recent work has implicated members of the evolutionarily conserved family of coronin proteins - in particular coronin 1 - in immune homeostasis. Coronins are involved in processes as diverse as pathogen survival in phagocytes and homeostatic T cell signalling. Notably, in both mice and humans, coronin mutations are associated with immune deficiencies and resistance to autoimmunity. In this article, we review what is currently known about these conserved molecules and discuss a potential common mechanism that underlies their diverse activities, which seem to involve cytoskeletal interactions as well as calcium-calcineurin signalling.

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