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Review
. 2013 Sep 7;42(17):7421-35.
doi: 10.1039/c3cs60094g. Epub 2013 Jun 13.

Multi-stimuli responsive macromolecules and their assemblies

Jiaming Zhuang  1 , Mallory R Gordon, Judy Ventura, Longyu Li, S Thayumanavan
Affiliations
Review

Multi-stimuli responsive macromolecules and their assemblies

Jiaming Zhuang et al. Chem Soc Rev. .

Abstract

In this review, we outline examples that illustrate the design criteria for achieving macromolecular assemblies that incorporate a combination of two or more chemical, physical or biological stimuli-responsive components. Progress in both fundamental investigation into the phase transformations of these polymers in response to multiple stimuli and their utilization in a variety of practical applications are highlighted. Using these examples, we aim to explain the origin of employed mechanisms of stimuli responsiveness which may serve as a guideline to inspire future design of multi-stimuli responsive materials.

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Figures

Figure 1
Figure 1
Structure of polymers sensitive to dual physical stimuli
Figure 2
Figure 2
Isomerization of azobenzene and salicylideneaniline
Figure 3
Figure 3
pH- and redox- responsive polymers
Figure 4
Figure 4
Structure of dual redox responsive polymer and pH/salt dual responsive polymer
Figure 5
Figure 5
Chemical and physical dual stimuli responsive polymers
Figure 6
Figure 6
Chemical and physical dual stimuli responsive polymers
Figure 7
Figure 7
Bio-related dual stimuli-responsive polymers
Figure 8
Figure 8
Responsive molecules sensitive to more than two stimuli
Scheme 1
Scheme 1
LCST behavior of PNIPAM
Scheme 2
Scheme 2
Representation of the two-stage thermally induced aggregation process
Scheme 3
Scheme 3
Schematic illustration of RPAE-PEG micelle dissociation and DOX release triggered by changing pH and DTT.
Scheme 4
Scheme 4
Chemical structure of the dual pH-responsive polymer-doxorubicin conjugate and pH triggered cellular internalization and intracellular drug release
Scheme 5
Scheme 5
a) Chemical structure of polymers, b) Schematic illustration for preparation and intracellular trafficking of ternary cross-linked polyplex
Scheme 6
Scheme 6
Temperature and pH mediated disassembly of electrostatically assembled nanoparticles.
Scheme 7
Scheme 7
Schematic representation of FRET processes modulated by pH and temperature
Scheme 8
Scheme 8
Fast and slow disassembly of micelles induced respectively by light and redox stimuli.
Scheme 9
Scheme 9
Enzymatic modulation of polymer morphologies
Scheme 10
Scheme 10
Sugar and OH− responsive permeable nanoreactor
Scheme 11
Scheme 11
Schematic representation of block copolymer combined pH, thermo and reduction sensitivity
Scheme 12
Scheme 12
Multiple stimuli responsive polyelectrolyte/surfactant complex micelles.
See this image and copyright information in PMC

References

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