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. 2013 Aug;85(8):1485-90.
doi: 10.1002/jmv.23603.

One year survey of human rotavirus strains suggests the emergence of genotype G12 in Cameroon

Valentine N Ndze  1 , Hajnalka Papp, Eric A Achidi, Kamga H Gonsu, Brigitta László, Szilvia Farkas, Péter Kisfali, Béla Melegh, Mathew D Esona, Michael D Bowen, K Bányai, Jon R Gentsch, Abena M T Odama
Affiliations

One year survey of human rotavirus strains suggests the emergence of genotype G12 in Cameroon

Valentine N Ndze et al. J Med Virol. 2013 Aug.

Abstract

In this study the emergence of rotavirus A genotype G12 in children <5 years of age is reported from Cameroon during 2010/2011. A total of 135 human stool samples were P and G genotyped by reverse transcriptase PCR. Six different rotavirus VP7 genotypes were detected, including G1, G2, G3, G8, G9, and G12 in combinations with P[4], P[6] and P[8] VP4 genotypes. Genotype G12 predominated in combination with P[8] (54.1%) and P[6] (10.4%) genotypes followed by G1P[6] (8.2%), G3P[6] (6.7%), G2P[4] (5.9%), G8P[6] (3.7%), G2P[6] (0.7%), G3P[8] (0.7%), and G9P[8] (0.7%). Genotype P[6] strains in combination with various G-types represented a substantial proportion (N=44, 32.6%) of the genotyped strains. Partially typed strains included G12P[NT] (2.2%); G3P[NT] (0.7%); G(NT)P[6] (1.5%); and G(NT)P[8] (0.7%). Mixed infections were found in five specimens (3.7%) in several combinations including G1+ G12P[6], G2+ G3P[6] + P[8], G3+ G8P[6], G3 + G12P[6] + P[8], and G12P[6] +P[8]. The approximately 10% relative frequency of G12P[6] strains detected in this study suggests that this strain is emerging in Cameroon and should be monitored carefully as rotavirus vaccine is implemented in this country, as it shares neither G- nor P-type specificity with strains in the RotaTeq® and Rotarix® vaccines. These findings are consistent with other recent reports of the global spread and increasing epidemiologic importance of G12 and P[6] strains.

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Figures

Fig. 1.
Fig. 1.
Rotavirus G and P genotypes combinations circulating in Northern Cameroon (North West: Esu and Bamenda; Far North: Maroua).
See this image and copyright information in PMC

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