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. 2013 Jun 13:2013:bat039.
doi: 10.1093/database/bat039. Print 2013.

TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions

Alicia P Higueruelo  1 , Harry Jubb, Tom L Blundell
Affiliations

TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions

Alicia P Higueruelo et al. Database (Oxford). .

Abstract

TIMBAL is a database holding molecules of molecular weight <1200 Daltons that modulate protein-protein interactions. Since its first release, the database has been extended to cover 50 known protein-protein interactions drug targets, including protein complexes that can be stabilized by small molecules with therapeutic effect. The resource contains 14 890 data points for 6896 distinct small molecules. UniProt codes and Protein Data Bank entries are also included. Database URL: http://www-cryst.bioc.cam.ac.uk/timbal

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Figures

Figure 1.
Figure 1.
Schema of the database showing all tables and fields.
See this image and copyright information in PMC

References

    1. Higueruelo AP, Schreyer A, Bickerton GRJ, et al. Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database. Chem. Biol. Drug Des. 2009;74:457–467. - PubMed
    1. Berman HM, Westbrook J, Feng Z, et al. The protein data bank. Nucleic Acids Res. 2000;28:235–242. - PMC - PubMed
    1. Bourgeas Rl, Basse MJ, Morelli X, et al. Atomic analysis of protein-protein interfaces with known inhibitors: The 2P2I database. PLoS One. 2010;5:e9598. - PMC - PubMed
    1. Morelli X, Bourgeas R, Roche P. Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I) Curr. Opin. Chem. Biol. 2011;15:475–481. - PubMed
    1. Basse MJ, Betzi S, Bourgeas R, et al. 2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions. Nucleic Acids Res. 2013;41:D824–D827. - PMC - PubMed

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