Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Jun 12;13(6):629-31.
doi: 10.1016/j.chom.2013.05.015.

Staphylococcus aureus osteomyelitis: bad to the bone

Michael E Olson  1 , Alexander R Horswill
Affiliations
Comment

Staphylococcus aureus osteomyelitis: bad to the bone

Michael E Olson et al. Cell Host Microbe. .

Abstract

Osteomyelitis is a debilitating bone infection often caused by the bacterial pathogen Staphylococcus aureus. In this issue, Cassat et al. (2013) develop a high-resolution microcomputed tomography (microCT) method to visualize bone remodeling during S. aureus infection and discover that the metalloprotease aureolysin plays a critical role in modulating osteomyelitis pathogenesis.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Imaging S. aureus-induced pathologic bone remodeling during osteomyelitis
S. aureus triggers profound alterations in bone remodeling during osteomyelitis (left image). Cassat et al. (2013) created imaging analysis algorithms to precisely quantify pathologic new bone formation (green) and cortical bone destruction (yellow), enabling comparison of the destructive capacity of different staphylococcal strains. Image provided courtesy of Dr. James Cassat, Vanderbilt University School of Medicine, USA.
See this image and copyright information in PMC

Comment on

References

    1. Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host & Microbe. 2013 this issue. - PMC - PubMed
    1. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012;287:13889–13898. - PMC - PubMed
    1. Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician. 2011;84:1027–1033. - PubMed
    1. Kourbatova EV, Halvosa JS, King MD, Ray SM, White N, Blumberg HM. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA 300 clone as a cause of health care-associated infections among patients with prosthetic joint infections. Am J Infect Control. 2005;33:385–391. - PubMed
    1. Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis. 2003;36:1157–1161. - PubMed

MeSH terms