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Review
. 2013 Jun;3(3):238-44.
doi: 10.1016/j.coviro.2013.05.012. Epub 2013 Jun 13.

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update

Dirk P Dittmer  1 , Blossom Damania
Affiliations
Review

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update

Dirk P Dittmer et al. Curr Opin Virol. 2013 Jun.

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies. The virus is able to modulate pro-proliferative pathways to its advantage, while simultaneously inhibiting pro-apoptotic signaling pathways. These functions are carried out by multiple viral proteins acting in concert. The overall outcome is the survival and proliferation of the infected cell. Additionally, the virus also modulates innate immune pathways to allow for prolonged survival of the infected cell following primary infection, and during viral latency. Here we review the latest advances in our knowledge of KSHV pathogenesis.

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Figures

Figure 1
Figure 1
Gross pathology of internal KS lesions on the lung of an AIDS patient (with permission from Vincent J. Moylan).
Figure 2
Figure 2
Different histological examples of KS. Shown is immunohistochemistry for the KSHV LANA protein in brown (panels a to d) and Hematoxilin & Eosin (H&E) stain of lesions (panel f. – i.) . Panels e and j represent non-KS control. The samples were part of the first KS tissue microarray made available through the AIDS Cancer Specimen Resource (ACSR). Magnification 40x.
See this image and copyright information in PMC

References

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