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Review
. 2013 May;106(5):333-9.
doi: 10.1016/j.acvd.2013.02.003. Epub 2013 Mar 22.

Drug-induced valvular heart disease: an update

Michel Andrejak  1 , Christophe Tribouilloy
Affiliations
Review

Drug-induced valvular heart disease: an update

Michel Andrejak et al. Arch Cardiovasc Dis. 2013 May.

Abstract

Numerous reports have shown an unquestionable association between fibrotic valve disease and the following drugs: ergot alkaloids (such as methysergide and ergotamine), ergot-derived dopaminergic agonists (such as pergolide and cabergoline) and drugs metabolized into norfenfluramine (such as fenfluramine, dexfenfluramine and benfluorex). This review focuses on different aspects of drug-induced valvular heart disease: historical background; echocardiographic features; different drugs recognized as being responsible for valvular heart disease; and pathophysiology.

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