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. 2014 Aug;43(4):1021-30.
doi: 10.1093/ije/dyt065. Epub 2013 Jun 14.

Cohort profile: The study of respiratory pathogens in Andean children

Carlos G Grijalva  1 , Marie R Griffin  2 , Kathryn M Edwards  2 , John V Williams  3 , Ana I Gil  2 , Héctor Verastegui  2 , Stella M Hartinger  3 , Jorge E Vidal  2 , Keith P Klugman  2 , Claudio F Lanata  2
Affiliations

Cohort profile: The study of respiratory pathogens in Andean children

Carlos G Grijalva et al. Int J Epidemiol. 2014 Aug.

Abstract

We investigated respiratory pathogens in a prospective cohort study of young children living in the Peruvian Andes. In the study we assessed viral respiratory infections among young children, and explored interactions of viruses with common respiratory bacteria, especially Streptococcus pneumoniae. Through weekly household visits, data were collected on the signs and symptoms of acute respiratory illness (ARI), nasal samples were collected to test for viruses during episodes of ARI, and nasopharyngeal samples were collected on a monthly basis to monitor bacterial colonisation. We also collected data on vaccination coverage, patterns of social mixing, geographic information, and environmental and socio-demographic variables. Understanding the interaction of respiratory viruses with bacteria and its impact on the burden and severity of ARIs in rural areas of developing countries is critical to designing strategies for preventing such infections.

Keywords: Epidemiology; acute respiratory illness; children; influenza; pneumococcus.

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Figures

Figure 1.
Figure 1.
Composition of study cohort
Figure 2.
Figure 2.
Household visits and respiratory sample collection strategy
Figure 3.
Figure 3.
Algorithm for ARI assessment and sample collection. NP, nasopharyngeal
See this image and copyright information in PMC

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