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Multicenter Study
. 2013 Jun;28(6):848-54.
doi: 10.3346/jkms.2013.28.6.848. Epub 2013 Jun 3.

Health-related quality-of-life after percutaneous coronary intervention in patients with UA/NSTEMI and STEMI: the Korean multicenter registry

Mi-Jeong Kim  1 , Doo Soo Jeon, Hyeon-Cheol Gwon, Soo-Joong Kim, Kiyuk Chang, Hyo-Soo Kim, Seung-Jea Tahk; KOREAN MUSTANG Investigators
Affiliations
Multicenter Study

Health-related quality-of-life after percutaneous coronary intervention in patients with UA/NSTEMI and STEMI: the Korean multicenter registry

Mi-Jeong Kim et al. J Korean Med Sci. 2013 Jun.

Abstract

Compared with ST elevation myocardial infarction (STEMI), long-term outcomes are known to be worse in patients with unstable angina/non-STEMI (UA/NSTEMI), which might be related to the worse health status of patients with UA/STEMI. In patients with UA/NSTEMI and STEMI underwent percutaneous coronary intervention (PCI), angina-specific and general health-related quality-of-life (HRQOL) was investigated at baseline and at 30 days after PCI. Patients with UA/NSTEMI were older and had higher frequencies in female, diabetes and hypertension. After PCI, both angina-specific and general HRQOL scores were improved, but improvement was much more frequent in angina-related HRQOL of patients with UA/NSTEMI than those with STEMI (44.2% vs 36.8%, P < 0.001). Improvement was less common in general HRQOL. At 30-days after PCI, angina-specific HRQOL of the patients with UA/NSTEMI was comparable to those with STEMI (56.1 ± 18.6 vs 56.6 ± 18.7, P = 0.521), but general HRQOL was significantly lower (0.86 ± 0.21 vs 0.89 ± 0.17, P = 0.001) after adjusting baseline characteristics (P < 0.001). In conclusion, the general health status of those with UA/NSTEMI was not good even after optimal PCI. In addition to angina-specific therapy, comprehensive supportive care would be needed to improve the general health status of acute coronary syndrome survivors.

Keywords: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Health Status; Myocardial Infarction; Quality of Life.

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Conflict of interest statement

Pfizer Pharmaceuticals Korea Ltd supported this study but played no role in the study design, data collection, analysis, interpretation, manuscript writing, or decision to proceed with publication.

Figures

Fig. 1
Fig. 1
Changes of HRQOL in each group of UA/NSTEMI and STEMI. In EQ-5D index, scores increased significantly after PCI. The degree of improvement (Δ) is not different in both groups (P = 0.337). In all three SAQ subscales, scores at 30 days after PCI are significantly higher compared with the baseline in both groups. The degree of improvement is higher in patients with UA/NSTEMI than with STEMI.
Fig. 2
Fig. 2
The frequency of significant improvement in general and angina-specific HRQOL (ΔHRQOL). Compared with general HRQOL, significant improvement is more frequently observed in angina-specific HRQOL after PCI. Patients with UA/NSTEMI show much more improvement in angina-specific HRQOL than those with STEMI.
Fig. 3
Fig. 3
Sequentially adjusted 30-day EQ-5D index. Mean EQ-5D indices of UA/NSTEMI and STEMI groups are sequentially adjusted by demographic and clinical variables, medications and baseline SAQ QOL. P value for final adjusted scores was < 0.01. CCB, calcium channel blocker; CV history, previous history of significant cardiovascular events.
See this image and copyright information in PMC

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