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Case Reports
. 2013 May;28(3):207-9.
doi: 10.5001/omj.2012.56.

Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic Acid: a case series

Mohammed Al Huneini  1 , Fauzia Wasim, Khalil Al Farsi, Murtadha Al-Khabori, Salam Al Kindi
Affiliations
Case Reports

Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic Acid: a case series

Mohammed Al Huneini et al. Oman Med J. 2013 May.

Abstract

We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.

Keywords: ATRA; Acute promyelocytic leukaemia; All-trans retinoic acid; Fever; Scrotal ulcers.

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Figures

Figure 1
Figure 1
Showing well-circumscribed two scrotal ulcers (case 1)
See this image and copyright information in PMC

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