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Review
. 2013 Oct;21(10):1436-42.
doi: 10.1016/j.joca.2013.05.020. Epub 2013 Jun 14.

Osteoarthritis year in review 2013: biology

R F Loeser  1
Affiliations
Review

Osteoarthritis year in review 2013: biology

R F Loeser. Osteoarthritis Cartilage. 2013 Oct.

Abstract

The purpose of this review was to present highlights from the published literature on the topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate original research manuscripts published since the last OARSI meeting in 2012. From review of the published literature, common themes emerged as active areas of research over the past year including studies in the areas of epigenetics, Wnt signaling, the role of inflammatory pathways in OA, lubricin, fibroblast growth factor signaling, and studies on OA biology in bone. Key findings in these areas were summarized and implications for future therapies were discussed.

Keywords: Bone; Cartilage; Growth factors; Inflammation; Meniscus; Signaling; Synovium.

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Conflict of interest statement

Conflict of interests: The author has no competing interests.

Figures

Fig. 1
Fig. 1
Interactions among tissues and biological mediators that contribute to the biology of OA.
See this image and copyright information in PMC

References

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