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. 2013 Jul 22;52(30):7822-4.
doi: 10.1002/anie.201302749. Epub 2013 Jun 17.

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Kyoung Hwa Jang  1 , Sang-Jip Nam, Jeffrey B Locke, Christopher A Kauffman, Deanna S Beatty, Lauren A Paul, William Fenical
Affiliations

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete

Kyoung Hwa Jang et al. Angew Chem Int Ed Engl. .

Erratum in

  • Angew Chem Int Ed Engl. 2014 Jan 13;53(3):621

Abstract

Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

Keywords: anthrax; antibiotics; bacillus anthracis; natural products; polyketides.

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Figures

Figure 1
Figure 1
X-ray drawing of anthracimycin illustrating its absolute configuration.
See this image and copyright information in PMC

References

    1. As defined by the US Center for Disease Control, see: http://www.bt.cdc.gov/agent/anthrax/needtoknow.asp

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