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. 2013 Jul;94(1):19-23.
doi: 10.1038/clpt.2013.73.

SLC classification: an update

A Schlessinger  1 , S W Yee, A Sali, K M Giacomini
Affiliations

SLC classification: an update

A Schlessinger et al. Clin Pharmacol Ther. 2013 Jul.

Abstract

The 386 human SLC superfamily members are diverse in sequence, structure, and function. Using sequence similarity, we previously classified the SLC superfamily members and identified relationships among families. With the recent determination of new SLC structures and identification of previously unknown human SLC families, an update of our previous classification is timely. Here, we comprehensively compare the SLC sequences and structures and discuss the applicability of structure-based ligand discovery to key SLC members.

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References

    1. Atkinson HJ, Morris JH, Ferrin TE, Babbitt PC. Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS ONE. 2009;4:e4345. - PMC - PubMed
    1. Schlessinger A, et al. Comparison of human solute carriers. Protein science : a publication of the Protein Society. 2010;19:412–428. - PMC - PubMed
    1. Madhusudhan MS, Webb BM, Marti-Renom MA, Eswar N, Sali A. Alignment of multiple protein structures based on sequence and structure features. Protein Eng Des Sel. 2009;22:569–574. - PMC - PubMed
    1. Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–2504. - PMC - PubMed
    1. The Universal Protein Resource (UniProt) in 2010. Nucleic acids research. 2010;38:D142–D148. - PMC - PubMed

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